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China approves first-ever drug for acute mountain sickness prevention_我的网站

一 |     8月18日，走进承德市双滦区钒钛产业园的美富淦冶金材料科技有限公司冷轧厂，一卷卷银白色的冷轧钢带正排队下线，最薄的产品只有0.14毫米，不到两张A4纸的厚度。冷轧钢带是工业制造的基础材料。    

    Medicine File photo: VCG
China has granted marketing approval of its first drug for the prevention of acute mountain sickness, filling the long-standing gap in the domestic market where no such medications had been available, Science and Technology Daily reported on Tuesday.
The National Medical Products Administration (NMPA) has approved the marketing of acetazolamide sustained-release capsules, the report said. As the first specialized drug in China indicated for preventing of acute mountain sickness, its approval marks the end of the country's lack of dedicated preventive treatment for altitude illness. 
By inhibiting the activity of carbonic anhydrase, acetazolamide promotes the renal excretion of bicarbonate, corrects respiratory alkalosis caused by hypoxia at high altitudes, thereby regulating acid-base balance, optimizing respiratory status, elevating blood oxygen levels, and reducing the risk of onset at the source. 
In contrast to health products that only provide auxiliary regulatory effects, this medication has been validated through stringent clinical trials and stands as a specialized drug approved by the NMPA with a clear indication for prevention, said the report.
Led by principal investigator is Luobu Gesang, a deputy dean of the People's Hospital of Xizang Autonomous Region, the clinical trial was designed by his team and has yielded critical evidence to inform prevention strategies for altitude sickness that are specifically adapted to Chinese and Asian populations. 
"Previously, although acetazolamide had already been used internationally for the prevention of acute mountain sickness, China had long lacked an NMPA-approved acetazolamide formulation supported by rigorous clinical trials. Furthermore, the existing international formulations were short-acting tablets requiring multiple daily doses, and no drugs with the relevant indication were available on the domestic market for an extended period," said Luobu Gesang.
The sustained-release capsule approved this time not only fills this critical gap but also optimizes the dosage form, providing more reliable and convenient medication protection for the physical health and life safety of people entering high-altitude areas, he added.
Clinical trials showed that, compared with the placebo group, the incidence of acute mountain sickness in the medication group was significantly reduced, with the incidence of moderate-to-severe acute mountain sickness decreasing by 14.6 percent, according to the report.
Related research has been published in the international flagship journal of high-altitude medicine, High Altitude Medicine & Biology.
Global Times
。钢材轧得越薄，晶粒越细密，强度、韧性和冲压性能就越出色，产品附加值就越高。冷轧厂厂长张宝东说：“通过切割、冲压等工艺，这里的冷轧钢带可以做成手机背板、易拉罐、水杯、家用电器面板，还有安全带卡扣、离合器片、汽车冲压件等产品，已在千行百业得到广泛应用。”承德钒钛磁铁矿资源规模全国第二，占全国探明储量40%以上。过去，承德钒钛新材料产业热轧能力强，但冷轧深加工长期缺失，呈现“前端强、后端弱”特点，钒钛初级坯料大都外运加工，产品附加值外流。为延伸产业链条，填补区域内无冷轧产品的空白，2024年，美富淦公司在承德开工建设冷轧厂。2025年11月，冷轧厂竣工投产。走进车间内，1号和2号轧机正高速运转，一卷卷钒钛基础板材被轧制成薄如蝉翼的极薄钢带。

二 | “运到冷轧厂的基板通常厚2至6毫米，要轧成极薄钢带，好比将厚面饼擀成薄薄的饺子皮，力稍有不均，就会破皮露馅。”张宝东说，公司购置了具有国际领先水平的轧机，每台价格高达6000万元。搭载智能大脑的轧机，安装着众多传感器，可实时监测张力、辊缝等关键参数。技术人员只需在屏幕上输入产品的规格参数，轧机即可借助数字孪生技术自主调控全流程，实现了从设定到调节的精准控制，即便24小时连续作业，成品厚度误差也能精准控制在千分之五毫米以内。冷轧产品一上市，许多客户主动上门寻求合作。公司先后与海尔、LG等知名企业达成长期供货协议。“相比螺纹钢，承德钒钛资源优势在板材中更能发挥其真正价值。含有钒钛的板材相较其他产品，拉伸、冲压、韧性、强度、抗腐蚀等各项指标都更胜一筹。”张宝东说，目前，公司产品已进入新能源、汽车制造、高端建材等高附加值领域，每吨附加值提升10%以上。近年来，美富淦先后在承德布局高端钒钛产品产业园、高端数字化系列冷轧生产制造产业园、高智能精密合金彩涂产业园。各园区功能定位清晰、产能互补联动、产业闭环运行，实现本地钒钛基板就地精深加工，填补了承德地区无冷轧产品的空白，推动产业链从粗放加工延伸至精细化制造。据介绍，美富淦还将陆续投产高端汽车钢、高强钢智能化产线，积极布局热成像新材料新兴赛道，持续丰富高端产品体系。（日报记者 陈宝云）。

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